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tissue_scaffold_technology_could_assist_in_rebuild_large_organs [2015/12/14 05:35] (current)
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 +**Tissue ‘scaffold’ technology could assist in rebuilding large organs** ​
 +‘Scaffold’ technology is the new tissue that scientists have developed that will enable the engineering of 
 +large organs. This research was led by the Universities of Bristol and Liverpool and it has shown that it is 
 +possible for cells to combine with a special scaffold to produce living tissue in the laboratory. Hopefully, ​
 +this can be implanted to patients as a way of replacing the diseased parts/​organs of the body. 
 +To this date, the approach is limited to growing small pieces of tissue, as larger dimensions reduce the 
 +oxygen supply to cells in the centre.
 +Dr. Adam Perriman led a team of researchers from the University of Bristol together with Professor ​
 +Anthony Hollander from the University of Liverpool in using cartilage tissue engineering as a model 
 +system for testing new method of overcoming the oxygen limitation problem.
 +They incorporated a new class of artificial membrane binding proteins that can be attached to stem 
 +cells. They attached an oxygen-carrying protein, myoglobin, to the stem cells before they are used to 
 +engineer cartilage. They ensure that each cell will have its own oxygen reservoir that it can access when 
 +the oxygen in the scaffold drops to dangerously low levels.
 +Dr. Perriman found out that from their preliminary experiments that they could produce these artificial ​
 +membrane binding proteins and paint the cells without affecting their biological function.
 +They were however surprised and delighted to discover that they could deliver the necessary quantity to 
 +the cells to supplement their oxygen requirements. ​
 +Their team’s findings was published June 17 in Nature Communications could really expand the 
 +possibilities in tissue engineering,​ not only in cartilage, but also for other tissues like cardiac muscle or 
 +Professor Hollander said that they have already shown that stem cells can help create parts of the body 
 +that can be successfully transplanted into patients and now they have found a way making their success ​
 +even better.
 +A huge challenge is growing large organs but with the recent technology, this can be overcome. To 
 +create larger pieces of cartilage gives a possible way of repairing some of the worst damage to human 
 +joint tissue, such as the weakening changes seen in hips or knee osteoarthritis or severe knee injuries ​
 +caused by major trauma- road traffic accidents or injuries incurred in war. 
 +Their new methodology,​ to describe the conversion of a normal protein into membrane binding protein, ​
 +is likely to pave way in the development of a wide range of new biotechnologies.
 +Development of a method of creating cartilage cells from stem cells is Professor Hollander’s pioneering ​
 +work. This has helped making it possible for the first successful transplant of a tissue-engineered trachea ​
 +by utilizing patient’s own stem cells. ​
 +Dr. Perriman on the other hand, is an EPSRC Early Career Research Fellow and faculty member in the 
 +School of Cellular and Molecular Medicine at the University of Bristol. His pioneering research on the 
 +construction and study of novel synthetic bio molecular systems is one of his distinguished research.
 +1.Tissue ‘scaffold’ technology could help rebuild large organs [[http://​]]
tissue_scaffold_technology_could_assist_in_rebuild_large_organs.txt · Last modified: 2015/12/14 05:35 by elena